Genetic and Environmental Factors Trigger Allergy
 (NY, Reuters Health, 1/9/04

Dr. Frank D. Gilliland of the University of Southern California in Los Angeles, and team, studied genes that encode enzymes known as Glutathione-S-transferases, which mop up free radicals and can even detoxify diesel exhaust. Common mutations of these GST genes have been linked to asthma and airway sensitivity. An evaluation of GST genes in 19 patients who had allergic rhinitis and ragweed allergies showed that subjects with the most GST mutations were more likely to react strongly to other allergins after exposure to diesel exhaust. These findings show that air pollution amplifies allergy susceptibility, and, therefore, suggest that blocking the effects of air pollutants with antioxidants —like vitamins A, E and C —may also reduce overall allergic response.